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Description
APC Mouse Anti-Human CD288 Antibody (S-2966)Product Specification Host Mouse Antigen CD288 Synonyms Toll like receptor 8; TLR8 Accession Q9NR97 Clone Number S 2966 Antibody Type Mouse mAb Isotype IgG2a,k Application ICFCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution
Product Specification
| Host | Mouse |
| Antigen | CD288 |
| Synonyms | Toll-like receptor 8; TLR8 |
| Accession | Q9NR97 |
| Clone Number | S-2966 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD288 (also designated as Toll-like receptor 8, TLR8) is an 83 kDa type 1 transmembrane protein belonging to the TLR family, predominantly expressed in lung and peripheral blood leukocytes, and encoded by the TLR8 gene located on the X chromosome. It functions as an endosomal receptor that recognizes GU-rich single-stranded RNA (ssRNA) and G-rich oligonucleotides from viral pathogens (e.g., influenza, HIV, HCV), leading to recruitment of MyD88 and activation of NF-κB, thereby inducing proinflammatory cytokine synthesis and antiviral responses. Additionally, TLR8 (CD288) is involved in dendritic cell activation and the regulation of tumor growth, making it a target in cancer therapy research (e.g., ovarian cancer, lymphomas).
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