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Description
TBK1/NAK Recombinant Rabbit mAb (S-658-50)Product Specification Host Rabbit Antigen TBK1 NAK Synonyms Serine threonine protein kinase TBK1, NF kappa B activating kinase, T2K, TANK binding kinase 1 Immunogen Synthetic Peptide Location Cytoplasm Accession Q9UHD2 Clone Number S 658 50 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | TBK1/NAK |
| Synonyms | Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q9UHD2 |
| Clone Number | S-658-50 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:200 | |
| ICFCM | 1:200 | |
| ICC | 1:400 |
Background
TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis. As a non-canonical IKK, TBK1 is also involved in the non-canonical NFkB pathway. It phosphorylates p100/NF-κB2, which is subsequently processed in the proteasome and released as a p52 subunit. This subunit dimerizes with RelB and mediates gene expression.
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