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Description
Anti-human Claudin 18.2 Monoclonal Antibody (zolbetuximab)Product Specification Host Human Antigen Claudin 18. 2 Synonyms Claudin 18; CLDN18 Location Cell membrane Accession P56856 2 Clone Number S R700 Antibody Type Recombinant mAb Isotype IgG1,k Reactivity Hu Purification Protein A Concentration 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Background
Product Specification
| Host | Human |
| Antigen | Claudin 18.2 |
| Synonyms | Claudin-18; CLDN18 |
| Location | Cell membrane |
| Accession | P56856-2 |
| Clone Number | S-R700 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1,k |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
Claudin 18.2 monoclonal antibodies are a promising class of therapeutic agents targeting the Claudin 18.2 protein, a tight junction protein that is highly expressed in various cancers, including gastric, pancreatic, and ovarian cancers. In normal tissues, Claudin 18.2 is predominantly expressed in differentiated gastric mucosal cells, but its upregulation in tumor cells makes it an attractive target for cancer therapy. These monoclonal antibodies, such as Zolbetuximab, work by binding specifically to the extracellular domain of Claudin 18.2, inducing antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) to kill cancer cells.
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