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Description
APC-Cy7 Rat Anti-Mouse CD8α Antibody (S-353-45)Product Specification Host Rat Antigen CD8 Synonyms T cell surface glycoprotein CD8 alpha chain; T cell surface glycoprotein Lyt 2; Lyt 2; Lyt2; Cd8a Immunogen Recombinant Protein Location Cell membrane Accession P01731 Clone Number S 353 45 Antibody Type Rat mAb Isotype IgG1 Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2mg ml Conjugation APC Cy7 Physical Appearance Liquid Storage
Product Specification
| Host | Rat |
| Antigen | CD8α |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; Lyt-2; Lyt2; Cd8a |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P01731 |
| Clone Number | S-353-45 |
| Antibody Type | Rat mAb |
| Isotype | IgG1 |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2mg/ml |
| Conjugation | APC-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD8α is a crucial immune glycoprotein that serves as a co-receptor for the MHC I-peptide complex, facilitating the recognition of antigens presented by APCs (antigen-presenting cells) to T cells. It is a key component of the CD8 receptor complex, which is predominantly found on cytotoxic T lymphocytes (CTLs). CD8α can form either an α/β heterodimer with CD8β or an α/α homodimer, both of which play essential roles in CTL activation and function. By interacting with the TCR (T cell receptor) and MHC I molecules, CD8α helps recruit the LCK kinase, initiating multiple signaling pathways that drive the CTL-mediated immune response.
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