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Description
Alexa Fluor® 647 Rat Anti-Mouse CD226 Antibody (S-R625)Product Specification Host Rat Antigen Mouse CD226 Synonyms CD226 antigen; Platelet and T cell activation antigen 1; Pta1 Location Cell membrane Accession Q8K4F0 Clone Number S R625 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Rat |
| Antigen | Mouse CD226 |
| Synonyms | CD226 antigen; Platelet and T-cell activation antigen 1; Pta1 |
| Location | Cell membrane |
| Accession | Q8K4F0 |
| Clone Number | S-R625 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD226 (also known as DNAM-1) is a member of the immunoglobulin superfamily and is expressed on the surface of T cells, natural killer (NK) cells, monocytes, and macrophages. It enhances the activation, proliferation, and cytotoxic functions of T cells and NK cells by binding to its ligands CD155 and CD112 and activating downstream signaling pathways such as PI3K-AKT and VAV-1-ERK. CD226 plays a crucial role in anti-tumor immunity, with its high expression associated with better responses to immune checkpoint blockade therapies. However, its function can be inhibited by TIGIT, which competes with CD226 for binding to CD155, thereby dampening immune activation. CD226 is also involved in regulating the function of regulatory T cells (Tregs), and its absence in Tregs can exacerbate inflammatory diseases. Thus, CD226 holds potential not only in cancer immunotherapy but also in the study of autoimmune diseases.
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4.8 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
Well Researched and a Terrific Read
Format: Kindle
Thank you Rachel! I enjoyed this so much, it was an eye-opener. So much I didn't know.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 12, 2026
★★★★★ 5
5 Star
Format: Hardcover
Rachel is a very fine writer.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 19, 2026
★★★★★ 5
Informative
Format: Hardcover
Good read
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 28, 2026
★★★★★ 5
If we care about racism and white privilege, what should we do?
Format: Kindle
One hundred and fifty-two years ago, slavery ended in the United States. And yet the tentacles of that time touch lives every day, all these years later.
What can be done to make things better? Michael Eric Dyson, a sociology professor at Georgetown University, and an ordained Baptist minister, suggests that white people who care about the lives of black people should make individual reparations. In his book, Tears We Cannot Stop …A Sermon to White America, Dyson says, “{Black people} built a legacy of excellence and struggle and pride amidst one of the most vicious assaults on humanity in recorded history. That assault may have started with slavery, but it didn’t end there. The legacy of that assault, its lingering and lethal effect, continues to this day. It flares in broken homes and blighted communities, in low wages and social chaos, in self-destruction and self-hate too. But so much of what ails us—black people. That is—is tied up with what ails you—white folk, that is. We are tied together in what Martin Luther King Jr. called a single garment of destiny. Yet sewed into that garment are pockets of misery and suffering that seem to be filled with a disproportionate number of black people.”
The book, unlike Dyson’s other scholarly works, takes the form of a worship service, and uses the concept of an extended sermon, or jeremiad, to lead the reader through confession, repentence, and redemption “through the long night of despair to the bright day of hope.” In Dysons’s view, “whiteness is a problem to be struggled with,” and his book is of inestimable value in grappling with the struggle.
The book speaks at length of police brutality against black people, and fervently tries to create empathy in white readers. It includes an extraordinary bibliography of books which give insight and voice to black history, oppression, pain, achievement, and lives.
And it speaks of reparations, and our responsibility as white beneficiaries of an unequal system, to take concrete actions to right the wrong, the change our country and the lives of our black sisters and brothers and their children.
Dyson is imaginative, and has many suggestions for how an individual or group “I.R.A.”—an Individual Reparations Account. We could buy books for black college students, overpay our black accountant or hairdresser, pay the black person who cuts our grass double the amount on the bill, give to the United Negro College Fund, and more. He suggests that faith groups consider giving 10% of their revenues to a church I.R.A. In an interview in the New York Times Magazine, Dyson says, “If the sermon ain’t making you a little bit uncomfortable, it ain’t effective. Look, if it doesn’t cost you anything, you’re not really engaging in change: you’re engaging in convenience. I’m asking you to do stuff you wouldn’t ordinarily do. I’m asking you to think more seriously and strategically about why you possess and what you possess…..you ain’t got to ask the government, you don’t have to ask your local politician—this is what you, an individual, conscientious, ‘woke’ citizen can do.
I have read many—though surely not all—of the books Dyson recommends. I have grappled with white privilege as a mother of black children, a fighter against apartheid, a civil rights activist, a human being. I have never read anything which more cogently offers “woke whites” a path to being a part of the change. I urge you to read Tears We Cannot Stop …A Sermon to White America, and to take your place in the pantheon of people who help this country grow beyond its racist past.
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Reviewed in the United States on January 23, 2017
★★★★★ 5
Powerful and especially so read aloud by the author.
Format: Audio CD
Hearing this powerful book read by Dr Tyson made it doubly understandable and enlightening. I needed to hear the experience, hurt and anger expressed so incredibly honestly and with the power of his emotion. I saw the CDs here at a reasonable price and I am so much more aware hearing rather than reading this book. Dr Tyson teaches powerful historic and current systemic racial experience such as every white person will do well to encounter. If you want to learn more than you already know, listen to these CDs on Black experience from Dr Tyson. Could be disturbing to anyone who does not want to learn the truth he teaches. It’s so packed with truth I will listen to it more than once more. Thank you, Dr Tyson.
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Reviewed in the United States on July 3, 2025
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