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Description
Biotin Mouse Anti-Human CD23 Antibody (S-4517)Product Specification Host Mouse Antigen CD23 Synonyms Low affinity immunoglobulin epsilon Fc receptor; BLAST 2; C type lectin domain family 4 member J; Fc epsilon RII; Immunoglobulin E binding factor; Lymphocyte IgE receptor; CD23A; CLEC4J; FCE2; IGEBF; FCER2 Location Secreted, Cell membrane Accession P06734 Clone Number S 4517 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G
Product Specification
| Host | Mouse |
| Antigen | CD23 |
| Synonyms | Low affinity immunoglobulin epsilon Fc receptor; BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD23A; CLEC4J; FCE2; IGEBF; FCER2 |
| Location | Secreted, Cell membrane |
| Accession | P06734 |
| Clone Number | S-4517 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD23, also known as the low-affinity IgE receptor (FcεRII), is a type II transmembrane glycoprotein belonging to the C-type lectin superfamily that plays a pivotal and multifaceted role in regulating immune responses, particularly those involving Immunoglobulin E (IgE). Unlike the high-affinity receptor FcεRI found on mast cells and basophils, CD23 is primarily expressed on B cells, follicular dendritic cells, monocytes, macrophages, eosinophils, and platelets, where it exists in two isoforms: CD23a, which is constitutively expressed on activated B cells, and CD23b, whose expression is induced by interleukin-4 (IL-4). Functionally, CD23 acts as a critical regulator of IgE synthesis through a feedback mechanism where membrane-bound CD23 binds IgE-allergen complexes and presents them to CD21 on B cells to modulate antibody production, while its soluble form (sCD23), generated via proteolytic cleavage by ADAM10, can either enhance or suppress IgE synthesis depending on the context and act as a growth factor for B cells and monocytes. Beyond allergy and asthma pathogenesis, where elevated CD23 levels correlate with disease severity, this protein is involved in antigen presentation, cytokine release (such as IL-6 and TNF-α), cell adhesion via interactions with integrins like CD11b/CD18, and has been implicated in the progression of certain malignancies like chronic lymphocytic leukemia (CLL), making it a significant therapeutic target for monoclonal antibodies aimed at disrupting IgE-mediated pathways or inhibiting tumor growth.
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Exchange/Return Notes
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