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Description
MUC1 Mouse mAb (SDT-777-37)Product Specification Host Mouse Antigen MUC1 Synonyms Mucin 1, MUC 1, Breast carcinoma associated antigen DF3, Cancer antigen 15 3 (CA 15 3), Carcinoma associated mucin, Episialin, H23AG, Krebs von den Lungen 6 (KL 6), PEMT, Peanut reactive urinary mucin (PUM), Polymorphic epithelial mucin (PEM), Tumor associated epithelial membrane antigen (EMA), Tumor associated mucin Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P15941
Product Specification
| Host | Mouse |
| Antigen | MUC1 |
| Synonyms | Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3 (CA 15-3), Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6 (KL-6), PEMT, Peanut-reactive urinary mucin (PUM), Polymorphic epithelial mucin (PEM), Tumor-associated epithelial membrane antigen (EMA), Tumor-associated mucin |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P15941 |
| Clone Number | SDT-777-37 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P, ICC, IP, IF, ICFCM |
| Reactivity | Hu, Rt |
| Predicted Reactivity | Pr |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:200 | |
| IHC-P | 1:500-1:2000 | |
| ICC | 1:500 | |
| ICFCM | 1:2000 | |
| IF | 1:500 |
Background
MUC1 is a transmembrane protein normally expressed in glandular or luminal epithelial cells and hematopoietic cells and absent in skin epithelium and mesenchymal cells. Apical surface of almost all glandular and ductal epithelial cells, including respiratory, gastrointestinal, urogenital, hepatobiliary tracts, sebaceous and salivary glands. MUC1 is expressed in the central cells of pancreatic acini, intercalary duct epithelium, and interlobular duct epithelium, but not in the acinar epithelium, main pancreatic duct epithelium, and pancreatic islet epithelium. Overexpression is common in malignancies and leads to tumorigenesis. Increased expression is associated with poor prognosis of most carcinomas, including those involving breast, cervical, pancreatic, colorectal.
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