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Description
TRP2/DCT Recombinant Rabbit mAb (S-1749-19)Product Specification Host Rabbit Antigen TRP2 DCT Synonyms L dopachrome tautomerase; DCT; DT; L dopachrome Delta isomerase; Tyrosinase related protein 2 (TRP 2; TRP2); TYRP2 Immunogen Synthetic Peptide Location Melanosome Accession P40126 Clone Number S 1749 19 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample SK MEL 2, SK MEL 28 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | TRP2/DCT |
| Synonyms | L-dopachrome tautomerase; DCT; DT; L-dopachrome Delta-isomerase; Tyrosinase-related protein 2 (TRP-2; TRP2); TYRP2 |
| Immunogen | Synthetic Peptide |
| Location | Melanosome |
| Accession | P40126 |
| Clone Number | S-1749-19 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | SK-MEL-2, SK-MEL-28 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Tyrosinase-related protein-2 (TRP2), also known as Dopachrome tautomerase (DCT), is a key enzyme in the melanin biosynthetic pathway, primarily expressed in melanocytes, the pigment-producing cells. It is a member of the tyrosinase-related protein family and plays a crucial role in melanogenesis by converting Dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA), which is further oxidized to form melanin. This enzyme not only influences the quality and solubility of melanin but also contributes to cellular detoxification and stress resistance by modulating the production of cytotoxic and antioxidant melanin precursors. Additionally, DCT has been implicated in various biological processes, including protection against UV radiation and reactive oxygen species (ROS) damage in melanocytes. Mutations in the DCT gene can lead to oculocutaneous albinism type VIII (OCA8), highlighting its importance in pigmentation.
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