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Description
Alexa Fluor® 488 Rat Anti-Mouse CD197 (CCR7) Antibody (S-R528)Product Specification Host Rat Antigen CD197 (CCR7) Synonyms C C chemokine receptor type 7; C C CKR 7; CC CKR 7; CCR 7; Epstein Barr virus induced G protein coupled receptor 1 (EBI1; EBV induced G protein coupled receptor 1); MIP 3 beta receptor; Cmkbr7; Ebi1; Ebi1h Location Cell membrane Accession P47774 Clone Number S R528 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Purification Protein G Conjugation Alexa Fluor 488 Physical
Product Specification
| Host | Rat |
| Antigen | CD197 (CCR7) |
| Synonyms | C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1; EBV-induced G-protein coupled receptor 1); MIP-3 beta receptor; Cmkbr7; Ebi1; Ebi1h |
| Location | Cell membrane |
| Accession | P47774 |
| Clone Number | S-R528 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein G |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD197, also known as CCR7, is a protein encoded by the CCR7 gene in humans and belongs to the G protein-coupled receptor family. It is a transmembrane protein with seven transmembrane domains, which is coupled with heterotrimeric G proteins to transduce signals downstream through various signaling cascades. CCR7 binds to two ligands: the chemokines CCL19 and CCL21. The main function of CCR7 is to guide immune cells to immune organs such as lymph nodes, thymus, and spleen by detecting specific chemokines secreted by these tissues. It is expressed on adaptive immune cell types, including thymocytes, naive T and B cells, regulatory T cells, central memory lymphocytes, and dendritic cells. CCR7 plays a crucial role in the maturation of dendritic cells and the trafficking of T cells within secondary lymphoid organs.
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