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Description
Phospho-Chk2 (Thr68) Recombinant Rabbit mAb (S-2214-11)Product Specification Host Rabbit Antigen Phospho Chk2 (Thr68) Synonyms Serine threonine protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog (Hucds1; hCds1); Checkpoint kinase 2; CDS1; CHK2; RAD53; CHEK2 Immunogen Synthetic Peptide Location Nucleus Accession O96017 Clone Number S 2214 11 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample Camptothecin treated HeLa cells Purification Protein A Concentration 0.
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Chk2 (Thr68) |
| Synonyms | Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog (Hucds1; hCds1); Checkpoint kinase 2; CDS1; CHK2; RAD53; CHEK2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | O96017 |
| Clone Number | S-2214-11 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | Camptothecin treated HeLa cells |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
Background
Phospho-Chk2 (Thr68) is the phosphorylated, active form of checkpoint kinase 2 (Chk2), a serine/threonine protein kinase that acts as a key tumor suppressor and DNA-damage transducer; in response to double-strand breaks the PI3K-like kinase ATM rapidly phosphorylates Chk2 on threonine 68, inducing transient dimerization via phospho-Thr68–FHA domain interactions that license subsequent autophosphorylation in the activation loop, thereby generating fully active Chk2 monomers that enforce cell-cycle arrest by phosphorylating substrates such as p53, BRCA1 and the Cdc25 phosphatases, and whose pathway disruption is frequently observed in cancer.
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