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Description
CDS2 Recombinant Rabbit mAb (S-3670-56)Product Specification Host Rabbit Antigen CDS2 Synonyms Phosphatidate cytidylyltransferase 2; CDP DAG synthase 2; CDP DG synthase 2; CDP diacylglycerol synthase 2 (CDS 2); CDP diglyceride pyrophosphorylase 2; CDP diglyceride synthase 2; CTP: phosphatidate cytidylyltransferase 2 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession O95674 Clone Number S 3670 56 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity
Product Specification
| Host | Rabbit |
| Antigen | CDS2 |
| Synonyms | Phosphatidate cytidylyltransferase 2; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2 (CDS 2); CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | O95674 |
| Clone Number | S-3670-56 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HepG2, PC-3, HeLa, NIH/3T3, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:250 | Hu, Ms |
Background
CDP-diacylglycerol synthase 2 (CDS2), also known as CDP-DAG synthase 2, is a critical membrane-bound enzyme located primarily in the endoplasmic reticulum that catalyzes the conversion of phosphatidic acid and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG), serving as the committed and rate-limiting step in the de novo biosynthesis of major phospholipids such as phosphatidylinositol, phosphatidylglycerol, and cardiolipin. As one of two isoforms in mammals (the other being CDS1), CDS2 plays an indispensable role in maintaining cellular membrane integrity, facilitating intracellular signaling pathways dependent on phosphoinositides, and regulating lipid homeostasis, with its expression and activity being tightly linked to metabolic processes where dysregulation has been associated with various pathologies including lipodystrophy, insulin resistance, and altered susceptibility to viral infections due to its involvement in modifying host membrane composition required for viral replication.
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