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Description
Histone H3 (mono methyl K36) Recombinant Rabbit mAb (S-859-505)Product Specification Host Rabbit Antigen Histone H3 (mono methyl K36) Synonyms H3K36me Immunogen Synthetic Peptide Location Nucleus Accession P68431 Clone Number S 859 505 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Positive Sample HeLa, MCF7, Jurkat, NIH 3T3, Neuro 2a, mouse liver, PC 12, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 (mono methyl K36) |
| Synonyms | H3K36me |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-859-505 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, MCF7, Jurkat, NIH/3T3, Neuro-2a, mouse liver, PC-12, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:5000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| ICFCM | 1:500 | Hu |
Background
Histone H3 (mono methyl K36) refers to a variant of histone H3 where the 36th lysine residue (K36) undergoes monomethylation, a crucial epigenetic regulatory mark. This modification is catalyzed by histone methyltransferases (e.g., SETD2, NSD1) and dynamically regulated by demethylases (e.g., KDM2A). H3K36me1 primarily localizes to gene promoters and enhancer regions, where it associates with transcriptional activation. It plays key roles in maintaining chromatin accessibility, facilitating transcriptional elongation, and promoting DNA damage repair. Studies have linked aberrant H3K36me1 distribution to cancers (e.g., leukemia, glioblastoma) and developmental disorders.
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