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Description
Myelin protein zero Recombinant Rabbit mAb (SDT-1225-8)Product Specification Host Rabbit Antigen Myelin protein zero Synonyms Myelin protein P0; Myelin peripheral protein (MPP); MPZ Immunogen Synthetic Peptide Location Cell membrane Accession P25189 Clone Number SDT 1225 8 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms Positive Sample Human sciatic nerve, mouse sciatic nerve Predicted Reactivity Bv Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Myelin protein zero |
| Synonyms | Myelin protein P0; Myelin peripheral protein (MPP); MPZ |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P25189 |
| Clone Number | SDT-1225-8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms |
| Positive Sample | Human sciatic nerve, mouse sciatic nerve |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:500 | Hu |
Background
Myelin protein zero (P0, MPZ) is a 28–30 kDa type I transmembrane glycoprotein that constitutes 50–70 % of total protein in peripheral nervous system (PNS) compact myelin, where it is expressed continuously by myelinating Schwann cells until mature myelin is formed; its extracellular immunoglobulin-like domain mediates homophilic adhesion between apposing membrane pairs to generate the characteristic intraperiod line, while its short cytoplasmic tail cooperates with myelin basic protein to zipper the cytoplasmic faces, enabling the tight membrane stacking that gives PNS myelin its insulating properties, and mutations in the MPZ gene underlie a spectrum of incurable demyelinating peripheral neuropathies such as Charcot–Marie–Tooth disease by disrupting these adhesive and structural functions.
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