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Description
Alexa Fluor® 488 Rat Anti-Mouse CD49b Antibody (S-R543)Product Specification Host Rat Antigen CD49B Synonyms Integrin alpha 2; CD49 antigen like family member B; Collagen receptor; Platelet membrane glycoprotein Ia (GPIa); VLA 2 subunit alpha; Itga2 Location Membrane Accession Q62469 Clone Number S R543 Antibody Type Rat mAb Isotype IgM Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 1 mg ml Conjugation Alexa Fluor 488 Physical Appearance
Product Specification
| Host | Rat |
| Antigen | CD49B |
| Synonyms | Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia (GPIa); VLA-2 subunit alpha; Itga2 |
| Location | Membrane |
| Accession | Q62469 |
| Clone Number | S-R543 |
| Antibody Type | Rat mAb |
| Isotype | IgM |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.1 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μl per million cells in 100μl volume | Ms |
Background
CD49b, also known as integrin alpha-2, is a protein encoded by the CD49b gene in humans. It is a subunit of the integrin receptor family, specifically forming the VLA-2 receptor when paired with the beta-1 subunit. This receptor is primarily involved in mediating cell adhesion to collagen and laminin, playing a crucial role in various biological processes such as platelet aggregation, cell migration, and tissue repair. CD49b is expressed on various cell types, including natural killer cells and a subset of T cells, and has been implicated in immune responses and cancer progression. In cancer research, CD49b has been identified as a potential therapeutic target due to its role in promoting cell proliferation and invasion in certain malignancies.
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