SKU: 33241568813

Mouse Anti-Human CXCR6 Antibody (S-3884)

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Description

Mouse Anti-Human CXCR6 Antibody (S-3884)Product Specification Host Mouse Antigen CXCR6 Synonyms C X C chemokine receptor type 6; CXC R6; CXCR 6; CDw186; G protein coupled receptor STRL33; G protein coupled receptor bonzo; CD186; BONZO; STRL33; TYMSTR Location Cell membrane Accession O00574 Clone Number S 3884 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical

Product Specification


Host Mouse
Antigen CXCR6
Synonyms C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD186; BONZO; STRL33; TYMSTR
Location Cell membrane
Accession O00574
Clone Number S-3884
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

CXCR6 (C-X-C motif chemokine receptor 6), also known as STRL33 and T-lymphocyte-expressed seven-transmembrane domain receptor (TYMSTR), is a G protein-coupled receptor (GPCR) that specifically binds to its unique ligand CXCL16, a transmembrane chemokine that can also be cleaved to function as a soluble chemokine. CXCR6 is predominantly expressed on memory/effector T cells, natural killer T (NKT) cells, natural killer (NK) cells, and plasma cells, playing critical roles in immune cell trafficking, adhesion, and activation. The CXCR6-CXCL16 axis is essential for the recruitment and positioning of immune cells in various tissues, particularly in the liver, spleen, and inflamed sites, and has been implicated in numerous pathological conditions including chronic inflammation, autoimmune diseases, infectious diseases, and cancer. In oncology, CXCR6 expression on tumor-infiltrating lymphocytes (TILs) is associated with improved prognosis in certain cancers, while its expression on tumor cells can promote metastasis and disease progression. The receptor signals primarily through Gαi proteins, activating downstream pathways such as PI3K/AKT, MAPK/ERK, and calcium mobilization, thereby regulating cell migration, survival, and proliferation. Given its selective expression on activated immune cells and its involvement in disease pathogenesis, CXCR6 represents an attractive therapeutic target for immunomodulatory strategies and precision medicine approaches.

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SKU: 33241568813

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Reviewed in the United States on May 3, 2026
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Kelly
Lowell, US
★★★★★ 1
FALSE description/POOR business practice
These needle cartridges do NOT fit the Dr.pen Ultima M7-W as it states in description. Beware when buying because I noticed when doing the return that they keep $5.00 of your purchase price when you return. I NEVER would have ordered from here had I known that before my purchase! This is pretty ridiculous and VERY POOR business practice if you ask me , especially when their own description states that they will fit the pen I have. BOOOO!
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Becky Dvorak’s book is so informative and has great prayers. I really enjoy her books, they are a gift for your life.
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Reviewed in the United States on May 26, 2025

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