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Description
PGP9.5 Recombinant Rabbit mAb (S-R281)Product Specification Host Rabbit Antigen PGP9. 5 Synonyms Ubiquitin carboxyl terminal hydrolase isozyme L1, UCH L1, Neuron cytoplasmic protein 9. 5, Ubiquitin thioesterase L1 Location Cytoplasm Accession P09936 Clone Number S R281 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | PGP9.5 |
| Synonyms | Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Neuron cytoplasmic protein 9.5, Ubiquitin thioesterase L1 |
| Location | Cytoplasm |
| Accession | P09936 |
| Clone Number | S-R281 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:1000-1:50000 | |
| ICC | 1:500 | |
| ICFCM | 1:500 |
Background
PGP9.5 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of PGP9.5 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons (accounts for 1-2% of total brain protein), expressed specifically in neurons and testis/ovary. Another potentially protective function of PGP9.5 is its reported ability to stabilize monoubiquitin, an important component of the ubiquitin proteasome system. It is also associated with Alzheimer's disease, and required for normal synaptic and cognitive function.
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