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Description
FITC Mouse Anti-Human CD55 Antibody (S-3120)Product Specification Host Mouse Antigen DAF CD55 Synonyms Complement decay accelerating factor; CR; DAF Location Cell membrane Accession P08174 Clone Number S 3120 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample human peripheral blood Leukocytes Purification Protein A Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Mouse |
| Antigen | DAF/CD55 |
| Synonyms | Complement decay-accelerating factor; CR; DAF |
| Location | Cell membrane |
| Accession | P08174 |
| Clone Number | S-3120 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood Leukocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
Decay-accelerating factor (DAF, also known as CD55) is a complement regulatory protein that plays a crucial role in protecting cells from complement-mediated attack. It is a membrane lipid microdomain-associated, GPI-anchored protein that accelerates the decay of C3 and C5 convertases, which are essential for the downstream formation of the membrane attack complex (MAC) in the complement cascade. This action helps prevent excessive complement activation and subsequent cell damage. CD55 is involved in various physiological and pathological processes, including immune regulation, cancer progression, and tissue protection. In cancer, CD55 can promote malignant transformation, cell survival, angiogenesis, and inhibit apoptosis through intracellular signaling pathways such as JNK, JAK/STAT, MAPK/NF-κB, and LCK. Additionally, it is enriched in the cancer stem cell niche and can be induced by chemotherapeutics and hypoxic environments.
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4.2 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 5
Essential kit for those with fetch dogs
Size: 18in, Style: Sport
Now in our 3rd year, my Brittany and I are down to about 40 fetch tosses a day, some 14,600 tosses a year. The Chuck It launcher wears well, so, figure at least 5 years of use, for 73,000 tosses. That makes for a terrific value!
There are several key benefits of the Chuck It launchers: One is that you can chuck the ball further than you can throw, which allows you to exercise your dog more easily. The second is that you can pick up and launch the ball without touching it, which means NO slime! And, the Chuck It also gives extra reach when you have to retrieve a ball from sticker brambles.
Those are great features for anyone with a fetch dog. If you also happen to have a weak arm or shoulder, the Chuck It launchers provide nice throwing options. I generally throw underhanded. I can't get the full potential range, that way, but, I still get good, long tosses. I curl my second finger above the last bump on the handle, and use a good wrist flick along with arm swing. I've seen others throw side-arm with the Chuck It.
I had originally written a second review for the longer 25M Chuck It. Either I, or Amazon messed up, and it looks like I can have only this one review. So, here are my additional thoughts on the 25M: I bought the 25M so that I could throw the ball even further! The good news is, you really can chuck further, with the longer chucker. The bad news is, those longer throws do require more arm and shoulder strength than when using the 18M. This becomes more obvious when you've done 3 or 4 dozen throws. I would recommend the 25M only for those with the youth and/or strength to get the most out of it. Otherwise, I'd say, go with the 18M.
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Reviewed in the United States on March 11, 2016
★★★★★ 4
Will buy again
Size: 25in, Style: Sport
Fits the bill.
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Reviewed in the United States on May 28, 2025
★★★★★ 5
Must Have for Tiring Out Your Pup
Size: 25in, Style: Sport
The Chuckit! Sport 25M Dog Ball Launcher is an absolute must-have for any dog owner with an active pup! This thing takes fetch to a whole new level—effortless long throws, hands-free pickup (no more slobbery tennis balls!), and a comfortable grip that makes playtime easier and way more fun.
My dog absolutely loves it, and I love that it helps her burn off energy without tiring out my arm. The included medium ball is the perfect size for medium to large dogs, and the durable construction means it's built to last. If you're looking for a simple but game-changing way to upgrade fetch, this is it. Highly recommend!
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Reviewed in the United States on February 13, 2025
★★★★★ 5
My Niece dog loves it!
Size: 18in, Style: Sport
This ball launcher takes a bit of getting. used to, but it is really helpful for those of us who are not MLB pitchers! The launcher itself is a sturdy plastic that is not brittle yet not soft; when the ball is launched there is no destructive bending in the shaft. The handle is padded and ergonomically sound while the cup end cradles the ball but has cut-outs on each side for easy loading and unloading of the ball. It did take a bit of practice for me to get the hang of it, but for my husband and son it was much easier. The launcher works well to help us older, non-gifted athletes launch the ball farther and faster while saving the shoulder, elbow, and wrist (important if there is any arthritis). The ball fits nicely into the cup and releases easily.
The 2.5 size was too small for my Doberman, so we opted for the 3.5 in launcher. This smaller launcher and ball are now in the employ of my sister and her husband for their retriever-border collie mix, an 18 month old little fireball!. This is just the right size for her. My sister's husband has difficulty with arthritis and is neither quick on his feet nor able to stand very long. So the launcher comes in very handy. He can actually sit in a lawn chair and throw the ball repeatedly when their dog retrieves and returns it to him. That is a win- win!
Top 3 Likes:
-Easy to use
-Helps older pet owner
-Drives the ball farther and faster
Top 3 Dislikes:
-With repeated uses the edges of the launcher appear to get scuffed and scratched
-Some ingrained staining on the edges persists requiring scrubbing to remove
-There is a mild worry that with time the launcher may snap
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Reviewed in the United States on September 4, 2024
★★★★★ 5
My dog loves it
Size: 25in, Style: Sport
I am amazed at how far I can throw a tennis ball. My dog and I absolutely love this. What happens to work well with the squeaky balls?I get on amazon as well. I have one of these at home, And I keep another one in the truck.
Very durable, The balls have good bounce, My dog and I have a lot of fun with it. My dog doesn't chew much on balls, But this one seems like it's going to stand out, I love the versatility, Hey can handle almost ending ball that same size. Are you solid rubber bouncy balls, Squeak.
Ing tuba balls, Whiffle balls with all the holes in it, Even the squeaky chewing balls. As long as there are that same size.
love the product. I've been using them for a few years.
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Reviewed in the United States on July 22, 2024
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