SKU: 33891626524

SEZ6 Recombinant Rabbit mAb,PBS Only(SDT-2097-737)

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Description

SEZ6 Recombinant Rabbit mAb,PBS Only(SDT-2097-737)Product Specification Host Rabbit Antigen SEZ6 Synonyms Seizure protein 6 homolog; SEZ 6; hSEZ 6 Immunogen Recombinant Protein Location Cell membrane Accession Q53EL9 Clone Number SDT 2097 737 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample H69 Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of

Product Specification


Host Rabbit
Antigen SEZ6
Synonyms Seizure protein 6 homolog; SEZ-6; hSEZ-6
Immunogen Recombinant Protein
Location Cell membrane
Accession Q53EL9
Clone Number SDT-2097-737
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample H69
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:10000 Hu
IHC-P 1:2000 Hu

Background

SEZ6 (Seizure-related gene 6) is a type I transmembrane glycoprotein (~110 kDa) composed of five short consensus repeat (SCR) domains, three CUB domains, a single transmembrane segment and a short cytoplasmic tail that is predominantly expressed in the central nervous system, where it acts as a critical trafficking chaperone for kainate receptor subunits GluK2/3, ensuring their proper N-glycosylation (including the HNK-1 epitope), post-ER export and surface localization to regulate synaptic connectivity, long-term potentiation and dendritic arbor balance, and is sequentially cleaved by BACE1 and γ-secretase to release a soluble ectodomain whose CSF level serves as a direct pharmacodynamic read-out of BACE1 inhibition, while in neuroendocrine neoplasms its selective over-expression is exploited as an ADC target for therapies against small-cell lung cancer and related tumors.

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SKU: 33891626524

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★★★★★ 5
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The book includes multiple full-length SAT practice tests that are same format and difficulty level of the real exam. Book covers questions from all sections—Reading, Writing, and Math Each question is accompanied by a thorough explanation, which will help students learn from their mistakes and improve their test-taking strategies. This is a must have as a study tool to prep for an exam.
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Great resource!
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This book is a great resource to have when prepping for the SAT. The diagnostic test is a huge help to see where you are before you dive into studying. The five practice tests include in depth explanations of the answers – that is a big help with studying. This is a great way to study for the digital SAT. Highly recommended!
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Lowell, US
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Excellent resource beyond Real Estate investing
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This book is hands down one of the best resources on key financial terms I have read yet. The authors explain many of the most important concepts in easy-to-understand language, building one’s understanding chapter upon chapter. I have ordered a dozen copies to hand out to my team as a reference guide for our group discussions. Whether you’re a newcomer to the profession and need to build a foundational understanding of the subject matter or are a more seasoned professional but would like a first-class teaching aid to assist in the development of others, this book covers all bases.
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Kindle Customer
West Palm Beach, US
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Great book . I really appreciate the questions at the end of each chapter that you must solve yourself it really makes this book a cut above the other real estate books I’ve read . Thank you
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Boise, US
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This book goes into such details of needed formulas and how to use them. Book has lots of examples of real world use and how to use the formulas. Well worth the purchase price.
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