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Description
PDGF R alpha/PDGFRA His Tag Protein, HumanProduct Specification Species Human Synonyms CD140A, PDGFR2, RHEPDGFRA, MGC74795 Accession P16234 1 Amino Acid Sequence Gln24 Glu524, with C 10*His Expression System HEK293 Molecular Weight 72 90kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | CD140A, PDGFR2, RHEPDGFRA, MGC74795 |
| Accession | P16234-1 |
| Amino Acid Sequence | Gln24-Glu524, with C-10*His |
| Expression System | HEK293 |
| Molecular Weight | 72-90kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Bruno Vincenzi. Andrea Napolitano.Mariella Spalato Ceruso. Francesco Pantano . Daniele Santini. Giuseppe Tonini. Olaratumab: PDGFR-α inhibition as a novel tool in the treatment of advanced soft tissue sarcomas. Crit Rev Oncol Hematol. 2017.06.006. Epub 2017 Jul 15. |
Background
PDGFR-α has been shown to regulate angiogenesis both in normal and pathological conditions, mainly stimulating the production of vascular endothelial growth factor (VEGF).PDGFR-α is expressed and active in several human malignancies. The most common alterations that lead to active PDGFR-α signaling in solid tumors are gene amplification in subsets of aggressive gliomas and non-small cell lung cancers,and activating mutations in c-KIT-negative GISTs. Among other cancers, PDGFR-α is also overexpressed in ~40% of hepatocellular carcinomas,~20% of non-GIST sarcomas,and ~15% of serous ovarian carcinoma.Finally, PDGFR-α translocations have been found in hematologic malignancies of the eosinophil lineage. Notably, in malignant conditions PDGFR-α expression is usually not confined to cancer cells, but is also present in tumor-associated stromal cells, which provide paracrine factors that stimulate angiogenesis and extracellular matrix remodeling.Finally, PDGFR-α expression has been shown to be correlated to aggressive disease and significantly worse patient survival in pediatric high-grade gliomas and hepatocellular carcinoma.
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