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Description
IL-23 Protein, MouseProduct Specification Species Mouse Synonyms Interleukin 23 protein; IL 23 protein; SGRFIL 23p19CLMF p40IL 12 subunit p40NKSF2 Amino Acid Sequence Val22 Ala196&Met23 Ser335 Expression System CHO Molecular Weight 19. 7&35. 8 KDa Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer Lyophilized from a 0. 2 m filtered solution of PBS, pH7. 4. Reconstitution Always centrifuge
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-23 protein; IL-23 protein;SGRF；IL-23p19；CLMF p40；IL-12 subunit p40；NKSF2 |
| Amino Acid Sequence | Val22-Ala196&Met23-Ser335 |
| Expression System | CHO |
| Molecular Weight | 19.7&35.8 KDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Stability & Storage |
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Background
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
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