Pay in installments of $75.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 23 - Jul 28
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
FITC-Labeled EGFR Fc Chimera Protein, HumanProduct Specification Species Human Synonyms EGFR, ERBB, ERRP, HER1, mENA, ERBB1 Accession P00533 Amino Acid Sequence Leu25 Ser645, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | EGFR, ERBB, ERRP, HER1, mENA, ERBB1 |
| Accession | P00533 |
| Amino Acid Sequence | Leu25-Ser645, with C-terminal Human IgG1 Fc LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 110-125kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | FITC |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Schlessinger J. (2000) Cell signaling by receptor tyrosine kinases. Cell. 103(2): 211-225. 2、Giaccone G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-548. 3、Yarden Y. et al. (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2(2): 127-137. |
Background
The Epidermal Growth Factor Receptor (EGFR)is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
EGFR is activated after homodimerization or heterodimerization. Heterodimerization is an important mechanism that allows the activation of all EGFR in response to ligand stimulation. The activated EGFR binds to many signaling proteins and stimulates the activation of many signaling pathways. The specificity and potency of intracellular signaling pathways are determined by positive and negative regulators, the specific composition of activating ligand(s), receptor dimer components, and the diverse range of proteins that associate with the tyrosine phosphorylated C-terminal domain of the EGFR.EGFR is overexpressed or mutated in many cancers, especially in breast cancer, ovarian cancer, and non-small cell lung cancer. The overexpression and overactivation of EGFR is correlated with poor prognosis, drug resistance, cancer metastasis, and lower survival rate.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.7 ★★★★★
Based on 11 reviews
Sort
Product Reviews
★★★★★ 5
Best text about an essential therapeutic method
Group therapy is, in my opinion, a criminally neglected and underrated tool in the toolset of psychotherapy and medicine. Group reveals our attachment style and communication patterns with a clarity, efficiency, and force that no other form of psychological intervention can match -- every person on the planet should spend some time in a group dealing with his or her mental and/or emotional issues. The world would be a better place.
Irv Yalom probably knows more about group than any other person, and this guidebook is essential to anybody wanting to understand the form. Yalom explains group thoroughly, in an understandable but frequently profound manner. The main drawback is that the book may even be overly comprehensive, and its length is likely to intimidate non-professionals, which is a shame because the benefits of group need wider dissemination.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 19, 2013
★★★★★ 5
Yalom's Group Therapy "Bible" continues to be the gold standard in group work.
I have used Yalom's Group Therapy book since my doctoral training in the early 90's. His work is timeless and it is clear he is an individual who understands the heart and the soul of our work. I created and facilitate a 18 - 20 week Relationship Academy which is part didactic and part experiential. It is amazing to see the group dynamics play out as expected based on Yalom's work. I will often read from this text in the morning, so that my mind is prepared for the day. It often changes my perspective and opens my eyes to considering different interpretations of behavior and it encourages me to silence myself and allow the "process" to work. How very rewarding this is! I don't see how serious group work can be done without Yalom's influence. Thank you so much for the updated text. Barbara Tobias, PhD, MSN, RN, Clinical Psychologist and CEO of New Perspectives Psychotherapy and Consulting, Camp Springs MD.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 23, 2012
★★★★★ 4
Needs to be updated
Format: Hardcover
Excellent book, but now that it is 2019, it needs to be updated to reflect the current health care system. This book details average inpatient hospitalization stays as 10-90 days. The current average length of stay at an inpatient hospital is 3-15 days. So a lot of the information about how to run groups was not as applicable now - in the book, it assumed patients would be together in groups for weeks, but the reality is that sometimes patients are only together for a day or two.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2019
★★★★★ 5
Good
Format: Hardcover
Good quality used item. Good to read about Yalom's work in IP Psych.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 25, 2025
★★★★★ 5
Yalom Still Rules
Yalom is as relevant today as ever. Writing with art for science, Yalom offers insights and wisdom for clinical group practice that have changed the way I approach my whole life. If you have the luck to read this as an assigned text, you may be relieved by his novelistic approach and his integration of existential philosophy. If you are looking for the deep dive, he’s your guy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 29, 2021