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Description
NK1.1/CD161 Recombinant Rabbit mAb (S-428-32)Product Specification Host Rabbit Antigen NK1. 1 CD161 Synonyms Killer cell lectin like receptor subfamily B member 1C, CD161 antigen like family member C, Lymphocyte antigen 55c (Ly 55c), NKR P1. 9, NKR P1C, Natural killer cell surface protein P1 40 (NKR P1 40), CD161c, Klrb1c Immunogen Recombinant Protein Location Membrane Accession P27814 Clone Number S 428 32 Antibody Type Recombinant mAb Application FCM Reactivity Ms Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | NK1.1/CD161 |
| Synonyms | Killer cell lectin-like receptor subfamily B member 1C, CD161 antigen-like family member C, Lymphocyte antigen 55c (Ly-55c), NKR-P1.9, NKR-P1C, Natural killer cell surface protein P1-40 (NKR-P1 40), CD161c, Klrb1c |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P27814 |
| Clone Number | S-428-32 |
| Antibody Type | Recombinant mAb |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:50 | null |
Background
CD161 is a C-type lectin-like membrane receptor expressed at high levels on NK, NKT, Th17, Mucosa Associated Invariant T cells (MAITs), non-MAIT CD8+, tissue-resident memory cells (TRMs), αβ CD4+ T cells and CD8+ T cells. CD161 levels increase when αβ T cells enter tissues. The ligand for CD161 is the lectin-like transcript 1 (LLT1). CD161/LLT1 engagement inhibits NK cell function but can inhibit or enhance αβ T cell function depending on the co-stimulatory molecules involved. The inhibitory capacity of αβ T cells can be neutralized by blocking CD161. CD161 expression on γδ T cells is associated with enhanced IFN-γ and IL-17 production and enhanced endothelial transmigration.
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Exchange/Return Notes
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