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Description
Alexa Fluor® 488 Rat Anti-mouse CD206 (MMR) Antibody (S-R498)Product Specification Host Rat Antigen CD206 (MMR) Synonyms Macrophage mannose receptor 1; MMR; Mrc1 Location Endosome, Cell membrane Accession Q61830 Clone Number S R498 Antibody Type Rat mAb Isotype IgG2a,k Application ICFCM Reactivity Ms Purification Protein G Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C
Product Specification
| Host | Rat |
| Antigen | CD206 (MMR) |
| Synonyms | Macrophage mannose receptor 1; MMR; Mrc1 |
| Location | Endosome, Cell membrane |
| Accession | Q61830 |
| Clone Number | S-R498 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | ICFCM |
| Reactivity | Ms |
| Purification | Protein G |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD206, also known as the mannose receptor (MR) or mannose receptor C type 1 (MRC1), is a transmembrane glycoprotein that belongs to the C-type lectin family. It is predominantly expressed by tissue macrophages, dendritic cells, and certain lymphatic or liver endothelial cells. CD206 recognizes and mediates endocytosis of pathogens by binding to glycoproteins terminated with mannose. This receptor serves as a homeostatic receptor by binding and scavenging unwanted high mannose N-linked glycoproteins as well as pituitary hormones from the circulation. In addition, CD206 is a marker for the M2 phenotype of macrophages, which are involved in immunosuppression, tissue remodeling, and Th2 effector responses. Its expression is regulated by various cytokines and is considered a marker of an M2-like macrophage phenotype.
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