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Description
NMDA Receptor 1 (GluN1) Recombinant Rabbit mAb (S-2107-40)Product Specification Host Rabbit Antigen NMDA Receptor 1 (GluN1) Synonyms Glutamate receptor ionotropic, NMDA 1; GluN1; Glutamate [NMDA] receptor subunit zeta 1; N methyl D aspartate receptor subunit NR1 (NMD R1; hNR1); NMDAR1; GRIN1 Immunogen Synthetic Peptide Location Cell membrane, Endoplasmic reticulum, Synapse Accession Q05586 Clone Number S 2107 40 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | NMDA Receptor 1 (GluN1) |
| Synonyms | Glutamate receptor ionotropic, NMDA 1; GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1 (NMD-R1; hNR1); NMDAR1; GRIN1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Endoplasmic reticulum, Synapse |
| Accession | Q05586 |
| Clone Number | S-2107-40 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human brain, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
The NMDA Receptor 1 (GluN1) protein is an essential subunit of NMDA receptors, which are ligand-gated ion channels that play crucial roles in excitatory neurotransmission, synaptic plasticity, learning, and memory in the central nervous system. GluN1 is required for the formation and function of all NMDA receptor complexes, as it binds glycine or D-serine and provides structural support for the receptor. This subunit is widely expressed in neurons and undergoes alternative splicing to produce multiple isoforms, each with distinct functional and pharmacological properties. For example, the presence of exon 5 in GluN1 reduces agonist potency and accelerates receptor deactivation. Additionally, GluN1's intracellular carboxyl-terminal domain interacts with various proteins involved in receptor trafficking and anchoring at synapses. Abnormal activity of GluN1-containing receptors has been implicated in several neurological and psychiatric disorders, making it a target for therapeutic interventions.
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