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Description
Ferritin Heavy Chain Recombinant Rabbit mAbProduct Specification Host Rabbit Antigen Ferritin Heavy Chain Synonyms FTH1; FTH; FTHL6; OK SW cl. 84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation inducing gene 15 protein Immunogen Synthetic Peptide Location Cytoplasm, Lysosome Accession P02794 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Hm Positive Sample K562, CHO K1, HeLa, mouse liver, rat liver Purification Protein A Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Ferritin Heavy Chain |
| Synonyms | FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Lysosome |
| Accession | P02794 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Hm |
| Positive Sample | K562, CHO-K1, HeLa, mouse liver, rat liver |
| Purification | Protein A |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | |
| ICC | 1:50-1:200 |
Background
Ferritin Heavy Chain (FTH1) is a subunit of the iron storage protein Ferritin, primarily responsible for the oxidation and storage of iron ions to maintain cellular iron homeostasis and prevent iron-mediated oxidative damage. FTH1 possesses ferroxidase activity, enabling it to oxidize toxic ferrous iron (Fe²⁺) into stable ferric iron (Fe³⁺) and store it within the Ferritin protein shell. It plays a critical role in regulating iron metabolism, antioxidant stress, and cellular protection, with its expression modulated by iron levels, oxidative stress, and inflammatory signals. Dysfunction of FTH1 is associated with various diseases, including neurodegenerative disorders, cancer, and iron overload conditions. Additionally, FTH1 is involved in immune regulation and apoptosis processes.
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