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Description
Siglec-8 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Siglec8, SAF2, SAF2SAF 2, SAF 2, CD329 antigen, CDw329 Amino Acid Sequence Met17 Ala363, with C terminal hIgG1 Fc Expression System HEK293 Molecular Weight 72 75kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | Siglec8, SAF2, SAF2SAF-2, SAF-2, CD329 antigen, CDw329 |
| Amino Acid Sequence | Met17-Ala363, with C-terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 72-75kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Bradford A Youngblood, John Leung, Rustom Falahati, Jason Williams, Julia Schanin, Emily C Brock, Bhupinder Singh, Alan T Chang, Nenad Tomasevic, Christopher R Bebbington. Discovery, Function, and Therapeutic Targeting of Siglec-8. Cells. 2020 Dec 24;10(1):19. |
Background
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibody or with selective polyvalent sialoglycan ligands induced the cell death of eosinophils and inhibited mast cell degranulation. Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects.
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