Pay in installments of $31.25 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 29 - Sep 3
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
DcR3 His Tag Protein, HumanProduct Specification Species Human Synonyms Decoy receptor for Fas ligand, TNFRSF6B, TR6, Decoy receptor 3 Accession O95407 Amino Acid Sequence Val30 Ser195 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 20 30kDa (Reducing) Purity 95% by SDS PAGE Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | Decoy receptor for Fas ligand, TNFRSF6B, TR6, Decoy receptor 3 |
| Accession | O95407 |
| Amino Acid Sequence | Val30-Ser195 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 20-30kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Lin WW, Hsieh SL. Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer. Biochem Pharmacol. 2011 Apr 1;81(7):838-47. |
Background
DCR3 (Decoy Receptor 3), also known as TNFRSF6B, is a member of the tumor necrosis factor receptor superfamily. It is a soluble secreted protein lacking both transmembrane and intracellular death domains. DCR3 exerts its "decoy" function by competitively binding to ligands such as FasL, LIGHT, and TL1A, thereby blocking apoptosis signaling induced by these ligands. Beyond its classical anti-apoptotic role, DCR3 can also activate pathways including NF-κB through reverse signaling to regulate dendritic cell differentiation, macrophage polarization, and osteoclast formation, participating in immune modulation and inflammatory responses. Clinical studies have demonstrated that DCR3 is aberrantly elevated in various malignancies (gastric cancer, renal cell carcinoma, pancreatic cancer, etc.) and autoimmune diseases (Crohn's disease, rheumatoid arthritis), serving as a biomarker for disease prognosis assessment. Furthermore, neutralizing antibodies or siRNA-based interventions targeting DCR3 offer potential therapeutic strategies for tumor immunotherapy.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy