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Description
Biotinylated IL-21R Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms IL21R,CD360,NILR,CD360 antigen,CD360,IL 21 receptor,interleukin 21 receptor,interleukin 21 receptor Accession Q9HBE5 1 Amino Acid Sequence Cys20 Pro236 with Fc&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 65 80kDa (Reducing) Purity 95% by SDS PAGE ;> 85% SEC HPLC Conjugation Biotin Tag Avi Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose
Product Specification
| Species | Human |
| Synonyms | IL21R,CD360,NILR,CD360 antigen,CD360,IL-21 receptor,interleukin 21 receptor,interleukin-21 receptor |
| Accession | Q9HBE5-1 |
| Amino Acid Sequence | Cys20-Pro236 with Fc&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 65-80kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE ;> 85% SEC-HPLC |
| Conjugation | Biotin |
| Tag | Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Yan L, Zhang J, Guo D, Ma J, Shui SF, Han XW. [Corrigendum] IL‑21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR‑125a‑3p axis in gastric cancer. Int J Oncol. 2025 Sep;67(3):74. |
Background
Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. Mature human IL-21 R consists of a 213 amino acid (aa) extracellular domain (ECD) with 4 conserved cysteine residues, a fibronectin type III domain, and a WSxWS motif, followed by a 21 aa transmembrane domain and a 285 aa cytoplasmic domain with a Box 1 motif, a kinase domain, and several sites for tyrosine phosphorylation . Within the ECD, human IL-21 R shares 69% aa identity with mouse and rat IL-21 R, respectively. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.
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