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Description
IL-23 Protein MouseProduct Specification Species Mouse Synonyms SGRF,IL 23p19,CLMF p40,IL 12 subunit p40,NKSF2,IL 23,Interleukin 23 Accession P43432(p40)Q9EQ14 (p19) Amino Acid Sequence Val22 Ala196, with N terminal His Tag (p19) &Met23 Ser335 (p40) Expression System HEK293 Molecular Weight 22 & 43 48 kDa (Reducing) Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, 5% trehalose,
Product Specification
| Species | Mouse |
| Synonyms | SGRF,IL-23p19,CLMF p40,IL-12 subunit p40,NKSF2,IL-23,Interleukin-23 |
| Accession | P43432(p40)、Q9EQ14 (p19) |
| Amino Acid Sequence | Val22-Ala196, with N-terminal His Tag (p19) &Met23-Ser335 (p40) |
| Expression System | HEK293 |
| Molecular Weight | 22 & 43-48 kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, 5% trehalose, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Immunity 2000, 13(5):715-725. |
Background
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
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