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Description
Hint1 Recombinant Rabbit mAb (S-2693-67)Product Specification Host Rabbit Antigen Hint1 Synonyms Adenosine 5' monophosphoramidase HINT1; Desumoylating isopeptidase HINT1; Histidine triad nucleotide binding protein 1; Protein kinase C inhibitor 1; Protein kinase C interacting protein 1 (PKCI 1); HINT; PKCI1; PRKCNH1; HINT1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P49773 Clone Number S 2693 67 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC
Product Specification
| Host | Rabbit |
| Antigen | Hint1 |
| Synonyms | Adenosine 5'-monophosphoramidase HINT1; Desumoylating isopeptidase HINT1; Histidine triad nucleotide-binding protein 1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1 (PKCI-1); HINT; PKCI1; PRKCNH1; HINT1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P49773 |
| Clone Number | S-2693-67 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Ramos, HeLa, 293T, MCF7, HepG2, Jurkat, mouse brain, rat liver, COS-7 |
| Predicted Reactivity | Bv, Rb |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
HINT1 (histidine triad nucleotide-binding protein 1) is a ubiquitously expressed, 13.7 kDa zinc-binding homodimeric enzyme that hydrolyzes purine nucleotide phosphoramidates via a double-displacement mechanism while acting as a multifunctional scaffold; it couples μ-opioid and NMDA receptors to tune analgesia and addiction behavior, suppresses tumorigenesis by inhibiting MITF and β-catenin, and its loss-of-function mutations cause autosomal recessive axonal neuropathy with neuromyotonia, making it a key player in neuropsychiatric disorders, pain regulation, and cancer.
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