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Description
AIFM2/FSP1 Recombinant Rabbit mAb (S-2271-67)Product Specification Host Rabbit Antigen AIFM2 FSP1 Synonyms Ferroptosis suppressor protein 1; Apoptosis inducing factor homologous mitochondrion associated inducer of death (AMID); p53 responsive gene 3 protein; AMID; PRG3 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Mitochondrion, Cell membrane Accession Q9BRQ8 Clone Number S 2271 67 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms Positive Sample HeLa,
Product Specification
| Host | Rabbit |
| Antigen | AIFM2/FSP1 |
| Synonyms | Ferroptosis suppressor protein 1; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death (AMID); p53-responsive gene 3 protein; AMID; PRG3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Mitochondrion, Cell membrane |
| Accession | Q9BRQ8 |
| Clone Number | S-2271-67 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, MCF7, A172, NIH/3T3, mouse kidney, mouse liver |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:200 | Hu, Ms |
Background
AIFM2, also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), or p53-responsive gene 3 (PRG3), is a protein encoded by the AIFM2 gene in humans. It is a flavoprotein oxidoreductase that plays a crucial role in regulating ferroptosis, a form of cell death characterized by iron-dependent lipid peroxidation. FSP1 primarily localizes to the plasma membrane and lipid droplets, and it suppresses ferroptosis by reducing ubiquinone (CoQ10) to ubiquinol (CoQ10-H2) using NAD(P)H as a cofactor, thereby preventing lipid peroxidation. This protein is also involved in the reduction of other molecules, such as vitamin K, and has been implicated in tumorigenesis and resistance to therapy in certain cancer models.
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