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Description
Mrp4 Recombinant Rabbit mAb (S-2305-17)Product Specification Host Rabbit Antigen Mrp4 Synonyms ATP binding cassette sub family C member 4; MRP cMOAT related ABC transporter; Multi specific organic anion transporter B (MOAT B); Multidrug resistance associated protein 4; MOATB; MRP4; ABCC4 Immunogen Synthetic Peptide Location Cell membrane Accession O15439 Clone Number S 2305 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | Mrp4 |
| Synonyms | ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B (MOAT-B); Multidrug resistance-associated protein 4; MOATB; MRP4; ABCC4 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | O15439 |
| Clone Number | S-2305-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms |
| IHC-P | 1:1000 | Hu |
Background
Mrp4 protein, also known as multidrug resistance protein 4, is a member of the ATP - binding cassette (ABC) transporter family. It is an integral membrane protein that plays a crucial role in the efflux of various substances out of cells. Mrp4 can transport a wide range of substrates, including organic anions, nucleoside - derived metabolites, and certain drugs. This protein is expressed in multiple tissues such as the liver, kidneys, and intestines. Its function is important for maintaining cellular homeostasis by preventing the accumulation of potentially toxic substances within cells. Additionally, Mrp4 has implications in the pharmacokinetics of drugs, as it can influence the absorption, distribution, metabolism, and excretion of certain medications. In the context of disease, alterations in Mrp4 expression or function have been associated with drug resistance in cancer cells and may also be involved in the pathogenesis of some renal disorders.
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