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Description
Invivo Anti-Mouse CD40 Recombinant mAb (S-R456)Product Specification Host Rat Antigen CD40 Synonyms Tumor necrosis factor receptor superfamily member 5; B cell surface antigen CD40; Bp50; CD40L receptor; Tnfrsf5 Location Secreted, Cell membrane Accession P27512 Clone Number S R456 Antibody Type Rat mAb Isotype Rat IgG2a,k Application FCM, in vivo CD40 activation, in vitro B cell stimulation activation Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 5 mg
Product Specification
| Host | Rat |
| Antigen | CD40 |
| Synonyms | Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; Tnfrsf5 |
| Location | Secreted, Cell membrane |
| Accession | P27512 |
| Clone Number | S-R456 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a,k |
| Application | FCM, in vivo CD40 activation, in vitro B cell stimulation/activation |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Dilution
| application | dilution | species |
| FCM | 1:250 | Ms |
Background
This antibody recognizes the same epitope as clone FGK45. CD40, also known as TNFRSF5, is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily, primarily expressed on antigen-presenting cells such as dendritic cells, macrophages, and B cells. Its ligand, CD40L (CD154), is mainly found on activated T cells and is also expressed on platelets, endothelial cells, and smooth muscle cells. The interaction between CD40 and CD40L plays a crucial role in immune regulation, mediating a wide range of immune responses, including B cell proliferation, differentiation, and immunoglobulin class switching, as well as enhancing T cell activation and dendritic cell maturation. This interaction initiates intracellular signaling pathways involving TRAF proteins and leads to the activation of transcription factors such as NF-κB, which in turn regulate cytokine production and immune cell function. CD40 signaling is also implicated in metabolic processes, influencing glucose metabolism and lipid homeostasis, particularly in macrophages and endothelial cells. Dysregulation of the CD40-CD40L pathway is associated with various diseases, including immunodeficiency syndromes and autoimmune disorders.
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Exchange/Return Notes
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