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Description
Alexa Fluor® 647 Rat Anti-Mouse/Human CD49f Antibody (S-R707)Product Specification Host Rat Antigen CD49f Synonyms Integrin alpha 6; CD49 antigen like family member F; VLA 6; ITGA6 Location Cell membrane Accession P23229Q61739 Clone Number S R707 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample Human peripheral blood lymphocytes Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3%
Product Specification
| Host | Rat |
| Antigen | CD49f |
| Synonyms | Integrin alpha-6; CD49 antigen-like family member F; VLA-6; ITGA6 |
| Location | Cell membrane |
| Accession | P23229、Q61739 |
| Clone Number | S-R707 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | Human peripheral blood lymphocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu, Ms |
Background
CD49f, also known as integrin α6 subunit, is a type I transmembrane glycoprotein encoded by the ITGA6 gene. It belongs to the α-subfamily of integrins and can form heterodimers with β1 (CD29) or β4 (CD104) subunits to create functional receptors such as α6β1 or α6β4. These receptors play crucial roles in cell adhesion, migration, and signaling. CD49f is highly expressed in various cell types, including T cells, monocytes, platelets, epithelial cells, and certain stem cells. In cancer biology, CD49f has been identified as a marker for tumor-initiating cells (TICs) in hepatocellular carcinoma (HCC), where it is associated with cell stemness, immune evasion, and the formation of an immunosuppressive tumor microenvironment. Additionally, CD49f has been used as a marker for human astrocytes and has shown potential in studying neurodegenerative diseases.
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