SKU: 39703748605

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)

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Description

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)Product Specification Host Rabbit Antigen HDAC1 Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1 Immunogen Synthetic Peptide Location Nucleus Accession Q13547 Clone Number SDT 310 72 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, K562, NIH 3T3, C6 Predicted Reactivity Bv Purification Protein A Concentration 1 mg ml Conjugation HRP Physical Appearance Liquid Storage Buffer PBS,

Product Specification


Host Rabbit
Antigen HDAC1
Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1
Immunogen Synthetic Peptide
Location Nucleus
Accession Q13547
Clone Number SDT-310-72
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample HeLa, Jurkat, K562, NIH/3T3, C6
Predicted Reactivity Bv
Purification Protein A
Concentration 1 mg/ml
Conjugation HRP
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied.

Dilution


application dilution species
WB 1:10000 Hu, Ms, Rt

Background

Histone deacetylase 1 (HDAC1) is a key enzyme involved in the regulation of gene expression through the deacetylation of histone and non-histone proteins. As a zinc-dependent deacetylase, HDAC1 removes acetyl groups from lysine residues on histones, thereby tightening chromatin structure and inhibiting gene transcription. It is a component of several multiprotein complexes, such as the NuRD complex, which are involved in chromatin remodeling and transcriptional repression. HDAC1 plays a crucial role in various cellular processes, including cell cycle progression, differentiation, and development. In cancer, HDAC1 is often overexpressed and contributes to tumor progression by promoting cell proliferation and survival. For example, in colorectal cancer, HDAC1 enhances cell survival and proliferation in an ATG16L-dependent manner. Additionally, HDAC1 overexpression in cancer cells can be regulated by transcription factors like Sp1 and Sp3, which bind to the HDAC1 promoter and recruit other epigenetic modulators. In neurodegenerative diseases such as Alzheimer's disease, HDAC1 has been implicated in the regulation of oxidative DNA damage repair and synaptic function. Studies have shown that HDAC1 activity may be involved in the pathogenesis of Alzheimer's disease through its effects on DNA repair mechanisms and gene expression. HDAC1 is also a potential therapeutic target for neurological disorders, as HDAC inhibitors have shown promise in preclinical studies for treating conditions like Huntington's disease and Parkinson's disease.

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SKU: 39703748605

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