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Description
ABCA1 Recombinant Rabbit mAb (S-1887-25)Product Specification Host Rabbit Antigen ABCA1 Synonyms Phospholipid transporting ATPase ABCA1; ATP binding cassette sub family A member 1; ATP binding cassette transporter 1 (ABC 1; ATP binding cassette 1); Cholesterol efflux regulatory protein; ABC1; CERP Immunogen Synthetic Peptide Location Endosome, Cell membrane Accession O95477 Clone Number S 1887 25 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | ABCA1 |
| Synonyms | Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1 (ABC-1; ATP-binding cassette 1); Cholesterol efflux regulatory protein; ABC1; CERP |
| Immunogen | Synthetic Peptide |
| Location | Endosome, Cell membrane |
| Accession | O95477 |
| Clone Number | S-1887-25 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HepG2, U-87 MG, mouse liver, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
ABCA1 (ATP Binding Cassette Subfamily A Member 1) is a protein encoded by the ABCA1 gene, located on chromosome 9q31.1. It is a member of the ATP-binding cassette (ABC) transporter family, which uses energy from ATP hydrolysis to transport various substrates across cell membranes. ABCA1 specifically facilitates the efflux of cholesterol and phospholipids from cells to extracellular acceptors such as apolipoprotein A-I (APOA1), playing a crucial role in the formation of high-density lipoprotein (HDL) particles. This process is essential for reverse cholesterol transport (RCT), which helps remove excess cholesterol from tissues and prevents atherosclerosis. Mutations in the ABCA1 gene can lead to Tangier disease, a rare genetic disorder characterized by extremely low levels of HDL cholesterol and cholesterol accumulation in tissues.
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