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Description
IL-28A/IFN-λ2 Protein, MouseProduct Specification Species Mouse Synonyms Interferon lambda 2; IFN lambda 2; Interleukin 28A (IL 28A) Accession Q4VK74 Amino Acid Sequence Asp20 Val193, with C terminal 8*His Expression System HEK293 Molecular Weight 25 30 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to
Product Specification
| Species | Mouse |
| Synonyms | Interferon lambda-2; IFN-lambda-2; Interleukin-28A (IL-28A) |
| Accession | Q4VK74 |
| Amino Acid Sequence | Asp20-Val193, with C-terminal 8*His |
| Expression System | HEK293 |
| Molecular Weight | 25-30 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Nat Immunol. 2003 Jan;4(1):63-8. Epub 2002 Dec 2. |
Background
Interferon lambda 2 (IFN-λ2), also known as interleukin-28A (IL-28A), is a type III interferon that belongs to the interferon lambda family. IFN-λ2 is produced in response to viral infections and plays a crucial role in the innate immune response against viruses. It exerts antiviral effects by inducing the expression of interferon-stimulated genes (ISGs) that inhibit viral replication and spread. IFN-λ2 signals through the IFN-λ receptor complex, which consists of IL-10R2 and IL-28Rα subunits, leading to the activation of downstream signaling pathways involved in antiviral defense. IFN-λ2 is considered a promising therapeutic agent for the treatment of viral infections due to its potent antiviral properties and reduced potential for side effects compared to type I interferons.
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