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Description
MARCO(405-520) His Tag Protein, HumanProduct Specification Species Human Synonyms MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2 Accession Q9UEW3 Amino Acid Sequence Ser405 Val520, with N terminal His Expression System HEK293 Molecular Weight 14 17kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer 50mM Tris,0. 1M NaCl,0. 3M Arg, pH8. 0.
Product Specification
| Species | Human |
| Synonyms | MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2 |
| Accession | Q9UEW3 |
| Amino Acid Sequence | Ser405-Val520, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 14-17kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 50mM Tris,0.1M NaCl,0.3M Arg, pH8.0. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Sheetal, A. et al. (2008) J. Immunotoxicol. 5:151. |
Background
MARCO (macrophage receptor with collagenous structure), also known as SCARA2, is an 80 kDa type II transmembrane glycoprotein that belongs to the class A scavenger receptor family. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. Its expression is induced on Kupffer cells and alveolar macrophages by microbial infection, chemical irritants, and Th1 polarizing factors. MARCO binds LPS, lipoteichoic acid, and other determinants on Gram positive and negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2. MARCO is required for the organization of the splenic marginal zone and the interaction of local macrophages and B cells.
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