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Description
TdT Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen TdT Synonyms DNA nucleotidylexotransferase; Terminal addition enzyme; Terminal deoxynucleotidyltransferase (Terminal transferase); TDT; DNTT Immunogen Recombinant Protein Location Nucleus Accession P04053 Antibody Type Polyclonal antibody Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample Jurkat, Molt 4, mouse thymus, rat thymus Purification Immunogen Affinity Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | TdT |
| Synonyms | DNA nucleotidylexotransferase; Terminal addition enzyme; Terminal deoxynucleotidyltransferase (Terminal transferase); TDT; DNTT |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | P04053 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Jurkat, Molt-4, mouse thymus, rat thymus |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase that plays a crucial role in the immune system and DNA repair. Unlike most DNA polymerases, TdT can add nucleotides to the 3′-hydroxyl end of a DNA strand in a template-independent manner. This enzyme is primarily expressed in immature B and T lymphocytes and is essential for V(D)J recombination, a process that generates the vast diversity of antigen receptors in the adaptive immune system. By adding non-templated nucleotides (N-regions) at the junctions between V, D, and J gene segments, TdT significantly increases the diversity of T-cell receptors (TCRs) and B-cell receptors (BCRs), enhancing the immune system's ability to recognize a wide range of antigens. Additionally, TdT is involved in DNA repair, particularly in the non-homologous end joining (NHEJ) pathway, where it helps repair DNA double-strand breaks. Its ability to function without a template also makes TdT a valuable tool in biotechnology and genetic research, such as in DNA sequencing and end labeling techniques.
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