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Description
Mouse Anti-Human CD11/CD18 Antibody (S-2969)Product Specification Host Mouse Antigen CD18 Synonyms Integrin beta 2; MFI7; ITGB2; Integrin alpha L; CD11a; ITGAL; CD11A; Integrin alpha M; CR 3 alpha chain; CD11b; ITGAM; CD11B; CR3A; Integrin alpha X; Leu M5; CD11c; ITGAX; CD11C Location Cell membrane Accession P05107P20701P11215P20702 Clone Number S 2969 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human peripheral blood Leukocytes Purification Protein G
Product Specification
| Host | Mouse |
| Antigen | CD18 |
| Synonyms | Integrin beta-2; MFI7; ITGB2; Integrin alpha-L; CD11a; ITGAL; CD11A; Integrin alpha-M; CR-3 alpha chain; CD11b; ITGAM; CD11B; CR3A; Integrin alpha-X; Leu M5; CD11c; ITGAX; CD11C |
| Location | Cell membrane |
| Accession | P05107、P20701、P11215、P20702 |
| Clone Number | S-2969 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD18, also known as integrin β2, is a 95 kDa glycoprotein that is a crucial component of several β2 integrins. These integrins are heterodimeric type I transmembrane proteins composed of a variable alpha chain (CD11a-d) and the common beta chain CD18. The CD18 protein is encoded by the ITGB2 gene in humans. It plays a significant role in cellular adhesion and immune responses. When CD18 binds with different alpha chains, it forms various heterodimers such as lymphocyte function-associated antigen-1 (LFA-1) with CD11a, and Macrophage-1 antigen receptor (Mac-1) with CD11b. These heterodimers are involved in processes like leukocyte adhesion to endothelial cells, phagocytosis, and immune cell activation. Deficiencies in CD18 expression can lead to adhesion defects in white blood cells, impairing the immune system's ability to fight infections.
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