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Description
TNF-R2 Recombinant Rabbit mAb (SDT-2099-516)Product Specification Host Rabbit Antigen TNF R2 Synonyms Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2 (TNF R2); Tumor necrosis factor receptor type II (TNF RII; TNFR II); p75; p80 TNF alpha receptor; CD120b Immunogen Recombinant Protein Accession P20333 Clone Number SDT 2099 516 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against TNF
Product Specification
| Host | Rabbit |
| Antigen | TNF-R2 |
| Synonyms | Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2 (TNF-R2); Tumor necrosis factor receptor type II (TNF-RII; TNFR-II); p75; p80 TNF-alpha receptor; CD120b |
| Immunogen | Recombinant Protein |
| Accession | P20333 |
| Clone Number | SDT-2099-516 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against TNF-R1 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
TNF-R2, or Tumor Necrosis Factor Receptor 2 (also known as CD120b), is a membrane-bound receptor primarily expressed on immune and endothelial cells. It binds to TNF-alpha, a key inflammatory cytokine, but transmits different signals than the related TNF-R1. TNF-R2 activation generally promotes cell survival, proliferation, and immunoregulatory functions. Detection of TNF-R2, particularly its soluble form (sTNF-R2) shed into the bloodstream, has significant clinical importance. Measuring sTNF-R2 levels via techniques like ELISA serves as a stable biomarker for overall TNF system activity. Elevated levels indicate chronic inflammatory and immune activation, correlating with disease severity in conditions like rheumatoid arthritis, sepsis, and certain cancers. Its detection aids in monitoring disease progression and therapeutic response, offering insights into the inflammatory state more reliably than fluctuating TNF-alpha itself.
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