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Description
Alexa Fluor® 647 Rat Anti-Mouse IL-17A Antibody (S-R683)Product Specification Host Rat Antigen IL 17A Synonyms Interleukin 17A; IL 17; IL 17A; Cytotoxic T lymphocyte associated antigen 8 (CTLA 8); Ctla8; Il17; Il17a Location Secreted Accession Q62386 Clone Number S R683 Antibody Type Rat mAb Isotype IgG1,k Application ICFCM Reactivity Ms Positive Sample Th17 polarized C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage
Product Specification
| Host | Rat |
| Antigen | IL-17A |
| Synonyms | Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8); Ctla8; Il17; Il17a |
| Location | Secreted |
| Accession | Q62386 |
| Clone Number | S-R683 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Ms |
| Positive Sample | Th17 polarized C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1.25μl per million cells in 100μl volume | Ms |
Background
IL-17A protein a is key cytokine produced by various immune cells such as Th17 cells. It plays a crucial role in the immune response by promoting inflammation. It can induce the expression of various pro-inflammatory molecules in different cell types, including chemokines that recruit neutrophils and other immune cells to the site of infection or injury. IL-17A is involved in the defense against certain pathogens, but its excessive production is also associated with the pathogenesis of several autoimmune and inflammatory diseases like psoriasis and rheumatoid arthritis. Targeting IL-17A has become an important therapeutic strategy in the treatment of these conditions.
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