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Description
PF4 Recombinant Rabbit mAb (S-4220)Product Specification Host Rabbit Antigen PF4 Synonyms Platelet factor 4; PF 4; C X C motif chemokine 4; Iroplact; Oncostatin A; CXCL4; SCYB4 Location Secreted Accession P02776 Clone Number S 4220 Antibody Type Recombinant mAb Isotype IgG Application IHC P, ICC Reactivity Ms Positive Sample mouse splenocytes cells Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | PF4 |
| Synonyms | Platelet factor 4; PF-4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A; CXCL4; SCYB4 |
| Location | Secreted |
| Accession | P02776 |
| Clone Number | S-4220 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, ICC |
| Reactivity | Ms |
| Positive Sample | mouse splenocytes cells |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:2000 | Ms |
| ICC | 1:100 | Ms |
Background
Platelet factor 4 (PF4) is a 70–amino-acid, 7.8-kDa CXC chemokine stored in platelet α-granules and released upon activation, where it binds glycosaminoglycans such as heparin with ultra-high affinity, neutralizes the anticoagulant activity of heparin by bridging and clustering it on platelet or endothelial surfaces, and forms stable tetramers that can subsequently assemble into ultra-large immune complexes recognized by anti-PF4/heparin antibodies in heparin-induced thrombocytopenia (HIT), while also exerting broader immune-modulatory effects by recruiting and activating leukocytes, promoting neutrophil extracellular trap (NET) formation, enhancing monocyte adhesion and phagocytosis, and amplifying thrombo-inflammation in conditions such as sepsis, COVID-19, and atherosclerosis through interaction with receptors including CXCR3, TLR4, and FcγRIIA.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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