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Description
Biotinylated FcRn His&Avi Tag Protein, MouseProduct Specification Species Mouse Synonyms FCGRT & B2M Accession Q61559(FcGRT)&P01887(B2M) Amino Acid Sequence Ser22 Ser297 (FcRn); Ile21 Met119 (B2M) , with C terminal His and Avitag Expression System HEK293 Molecular Weight 43 50&12kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | FCGRT & B2M |
| Accession | Q61559(FcGRT)&P01887(B2M) |
| Amino Acid Sequence | Ser22-Ser297 (FcRn);Ile21-Met119 (B2M) , with C-terminal His and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 43-50&12kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Derry C. Roopenian，FcRn: the neonatal Fc receptor comes of age. |
Background
FcRn is an unusual Fc receptor, the biological importance of which is only beginning to be fully appreciated. In addition to its critical role in the transfer of maternal IgG to the fetus or neonate, FcRn is the homeostatic receptor responsible for extending the serum half-life of IgG in adults. The exact site(s) of IgG protection from degradation has not been delineated in vivo, but both endothelial cells and bone-marrow-derived cells can extend the serum persistence of IgG. FcRn is also expressed in many other tissues in the adult animal, including barrier sites such as the blood–brain interface, the glomerular filter in the kidneys and the intestinal epithelium. FcRn expression at these sites merits further study with the goals of modulating specific IgG transport to promote host defence or to control immune-complex deposition.
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