SKU: 42990243345

IMP-3 Recombinant Rabbit mAb (S-439-10)

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Description

IMP-3 Recombinant Rabbit mAb (S-439-10)Product Specification Host Rabbit Antigen IMP 3 Synonyms Insulin like growth factor 2 mRNA binding protein 3, IGF2 mRNA binding protein 3, IGF II mRNA binding protein 3, KH domain containing protein overexpressed in cancer (hKOC), VICKZ family member 3, IGF2BP3, KOC1, VICKZ3 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession O00425 Clone Number S 439 10 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM

Product Specification


Host Rabbit
Antigen IMP-3
Synonyms Insulin-like growth factor 2 mRNA-binding protein 3, IGF2 mRNA-binding protein 3, IGF-II mRNA-binding protein 3, KH domain-containing protein overexpressed in cancer (hKOC), VICKZ family member 3, IGF2BP3, KOC1, VICKZ3
Immunogen Recombinant Protein
Location Cytoplasm, Nucleus
Accession O00425
Clone Number S-439-10
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC, ICFCM
Reactivity Hu, Ms, Rt
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 null
IHC 1:200 null
ICC 1:500 null
ICFCM 1:500 null

Background

Insulin-like growth factor-II (IGF-II) messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the IGF-II mRNA-binding protein (IMP) family, which also includes IMP-1 and IMP-2. IMP-3 is a 580 amino-acid protein encoded by a 4350-bp mRNA transcript produced by a gene located on chromosome 7p11.5. As a translational activator of IGF-II leader-3 mRNA, it is associated with cell proliferation and is considered an oncofetal protein due to its expression during embryogenesis and in some malignancies. Normal adult tissues that express IMP-3 include term placenta, ovary, testis, brain, lymph node germinal centers, and intestinal mucosa. Increased levels of IMP-3 have been identified in pancreatic carcinoma, renal cell carcinoma, germ cell neoplasms, ovarian carcinoma, and extrapulmonary small-cell carcinoma, as well as high-grade neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma of the lung. Additionally, IMP-3 was shown to be a prognostic marker in patients with renal cell carcinoma, with lack of expression in the primary tumor predicting longer metastases-free survival.

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SKU: 42990243345

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Lena Y.
Charlottesville, US
★★★★★ 5
Nice so far.
Size: 6.5, Color: Molasses
Comfy. They were tight the first day across the toes but as I've worn them a couple times they are loosening up. The sole is forming to my foot. These are very much like Doc Martin's from the early 2000s. Not sure about quality since I haven't had them for very long.
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Reviewed in the United States on March 27, 2026
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Just Carrie
Bozeman, US
★★★★★ 5
Comfortable
Size: 6, Color: Black
Great sandal! Fits great and comfy
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Reviewed in the United States on April 3, 2026
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BJ Coyle
Chelsea, US
★★★★★ 5
Yes!
Size: 5, Color: Molasses
Love these, very comfortable. Tts
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Reviewed in the United States on June 13, 2026
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Nunca me llegó el pedido
Omaha, US
★★★★★ 5
Muy suaves
Size: 6.5, Color: Black
Son muy cómodas me encantaron
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Reviewed in the United States on June 11, 2026
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Jami
Omaha, US
★★★★★ 2
Not the best
Size: 7, Color: Black, Size: 7, Color: Black
They are cute but they have a bit of an odd fit that isn’t great for people with narrow feet. They look too dressy to wear with super casual outfits in my opinion. I think the Ugg golden star sandals are much comfier. If you’re wearing these sandals for a really short time they’d be okay. After wearing them around my house for a little while I decided to return them since they started to hurt my feet.
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Reviewed in the United States on June 7, 2026

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