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Description
IL-18 Recombinant Rabbit mAb (S-2142-2)Product Specification Host Rabbit Antigen IL 18 Synonyms Interleukin 18; Iboctadekin; Interferon gamma inducing factor (IFN gamma inducing factor); Interleukin 1 gamma (IL 1 gamma); IGIF; IL1F4; IL18 Immunogen Recombinant Protein Location Cytoplasm, Secreted Accession Q14116 Clone Number S 2142 2 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample PC 3, A431, HeLa, DU 145 Purification Protein A Concentration
Product Specification
| Host | Rabbit |
| Antigen | IL-18 |
| Synonyms | Interleukin-18; Iboctadekin; Interferon gamma-inducing factor (IFN-gamma-inducing factor); Interleukin-1 gamma (IL-1 gamma); IGIF; IL1F4; IL18 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Secreted |
| Accession | Q14116 |
| Clone Number | S-2142-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | PC-3, A431, HeLa, DU 145 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:2000 | Hu |
Background
Interleukin-18 (IL-18) is a 18 kDa pro-inflammatory cytokine of the IL-1 superfamily, constitutively expressed by macrophages, dendritic cells, and epithelial cells as an inactive 24 kDa pro-peptide that is cleaved by caspase-1 within the inflammasome to its mature form; once secreted, IL-18 binds the heterodimeric receptor IL-18Rα/IL-18Rβ and recruits the adaptor MyD88 to activate NF-κB and MAPK pathways, synergizing with IL-12 to drive IFN-γ production from Th1 cells and NK cells and promote cell-mediated immunity, but when unchecked it contributes to the pathogenesis of autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, and type 1 diabetes, making it both a biomarker and therapeutic target.
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