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Description
Alexa Fluor® 488 Mouse Anti-Human CD5 Antibody (S-2877)Product Specification Host Mouse Antigen CD5 Synonyms T cell surface glycoprotein CD5; Lymphocyte antigen T1 Leu 1; LEU1; CD5 Location Cell membrane Accession P06127 Clone Number S 2877 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human Peripheral Blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD5 |
| Synonyms | T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; LEU1; CD5 |
| Location | Cell membrane |
| Accession | P06127 |
| Clone Number | S-2877 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD5 is a 67 kDa type I cell surface glycoprotein that belongs to the scavenger receptor cysteine-rich (SRCR) family. It is expressed on all T cells and a subset of B cells known as B-1a cells. CD5 plays a crucial role in regulating T cell receptor (TCR) signaling and acts as a negative regulator of T cell activation. It helps fine-tune the threshold for T cell activation during thymocyte development and suppresses peripheral T cell activation by inhibiting TCR-proximal signaling. In B-1a cells, CD5 helps prevent self-reactivity by dampening B cell receptor (BCR) signals. The expression of CD5 is also associated with cell survival, apoptosis, and the development of regulatory T cells. Additionally, CD5 may be involved in the regulation of dendritic cell function and cytokine production.
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