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Description
PODXL Recombinant Rabbit mAb (S-2014-9)Product Specification Host Rabbit Antigen PODXL Synonyms Podocalyxin; GCTM 2 antigen; Gp200; Podocalyxin like protein 1 (PC; PCLP 1); PCLP; PCLP1 Immunogen Synthetic Peptide Location Cell membrane Accession O00592 Clone Number S 2014 9 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HT 29, HeLa, Caco 2, mouse kidney Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | PODXL |
| Synonyms | Podocalyxin; GCTM-2 antigen; Gp200; Podocalyxin-like protein 1 (PC; PCLP-1); PCLP; PCLP1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | O00592 |
| Clone Number | S-2014-9 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HT-29, HeLa, Caco-2, mouse kidney |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:5000 | Hu, Ms, Rt |
Background
Podocalyxin-like protein 1 (PODXL) is a type I transmembrane protein belonging to the CD34 family of sialomucins, typically expressed in kidney podocytes, vascular endothelial cells, hematopoietic progenitors, mesothelium, and certain neurons. It has a highly glycosylated extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. PODXL functions primarily as an anti-adhesive molecule, regulating cell morphology and adhesion, and is crucial for kidney development and function. In cancer, PODXL is often overexpressed and associated with aggressive tumor phenotypes, poor prognosis, and potentially chemoresistance.
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