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Description
RNF43 mFc Chimera Protein, MouseProduct Specification Species Mouse Synonyms RNF43, RING finger protein 43 Accession Q5NCP0 Amino Acid Sequence Ala34 Tyr197, with C terminal mIgG2a Fc Expression System HEK293 Molecular Weight 55 60kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Mouse Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | RNF43, RING finger protein 43 |
| Accession | Q5NCP0 |
| Amino Acid Sequence | Ala34-Tyr197, with C-terminal mIgG2a Fc |
| Expression System | HEK293 |
| Molecular Weight | 55-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Mouse Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Radaszkiewicz T. et al. (2021) RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion. eLife Sciences. 10. |
Background
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A- induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunoprecipitation showed that RNF43 can interact with the core receptor complex components dedicated to the noncanonical Wnt pathway such as ROR1, ROR2, VANGL1, and VANGL2. RNF43 triggers VANGL2 ubiquitination and proteasomal degradation and clathrin- dependent internalization of ROR1 receptor and inhibits ROR2 activation. These activities of RNF43 are physiologically relevant and block pro-metastatic WNT5A signaling in melanoma. RNF43 inhibits responses to WNT5A, which results in the suppression of invasive properties of melanoma cells.
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4.1 ★★★★★
Based on 20 reviews
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Product Reviews
★★★★★ 5
great room divider
This room divider is very nice, good fabric, blocks light, not entirely bit alot for my needs. covers or blocks
what i dont want others to see, the assembly was some difficulty but he end product is fantastic.. i recommend fully.. thank you for a great product
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Reviewed in the United States on December 25, 2024
★★★★★ 4
Offers Complete Privacy
Color: Black, Size: 132in-Large Metal Base
We tried others that were nice but this particular room divider adds total privacy. We were looking for that. Easy to assemble. There is no gap if you position each petition close enough. The guality is very nice. Exactly what we were looking for.
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Reviewed in the United States on June 24, 2025
★★★★★ 5
Light and easy to move around! Still sturdy and tall like I wanted.
Color: Grey, Size: 2 Large Panels
Easily put together, work excellently for a room divider and taller than I am at 5'9" so that makes the privacy really great for our purposes. The feet turn and so you can get them out of a pathway as needed, the middle one that has two posts in it does not move but the end ones do. Very LIGHT so not hard to move around. Fabric is not see through. We have a lamp on one side and you can see the light through it but that is not an issue for us. The price is right!! most cubicle kinds of walls are so, so, so much money. With these being light and still give privacy the price was great. If you want them for sound, this is not the product for you but really most cubicle calls are not going to give you privacy other than visually anyway and these do that well. The size was accurate and so fit exactly how I needed them to and that was an important point for me. I used both of them in L shapes for my room and the size was right on.
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Reviewed in the United States on August 8, 2025
★★★★★ 5
Almost perfect
Color: Black, Size: 2 Large Panels, Color: Black, Size: 2 Large Panels
The cloth material is sturdy and fits well on the design. Both sides are black and you can't tell a difference between each side. It's extremely light weight and easily movable. We got a double and a single and the single is used as a sliding door. It's definitely not the MOST stable thing but overall it's pretty stable, probably won't work GREAT on carpet. It's not see through at all, which is great, the only downfall is the gap between the two sides. We are using a blanket to cover the gap. It's not 6 foot tall, but you can adjust the feet on it to be taller. Overall it's a great product for the price and can easily be moved out of they way.
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Reviewed in the United States on September 5, 2024
★★★★★ 5
A decent buy
Color: Black, Size: 1 Large Panel
Easy to assemble, good quality fabric, the two horizontal "feet" are supposed to be stabilized by a knob/screw but its always looosening up with even the slightest move, so the only unfortunate thig is that it requires constant turning to tighten it if you adjust its location even a teensy bit. I used it as a backdrop to hold a design of balloons, then since the party I use it as a "semi" partition in a bedroom. Good value for the money since it can be used over and over.
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Reviewed in the United States on June 24, 2025