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Description
TYK2 Recombinant Rabbit mAb (S-2740-165)Product Specification Host Rabbit Antigen TYK2 Synonyms Non receptor tyrosine protein kinase TYK2 Immunogen Recombinant Protein Location Cytoplasm, Cytoskeleton, Nucleus Accession P29597 Clone Number S 2740 165 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample MCF7, Jurkat, HeLa, U 87 MG, SH SY5Y, Neuro 2a, mouse lung, C6, rat lung Predicted Reactivity Cz Purification Protein A Concentration 2 mg ml
Product Specification
| Host | Rabbit |
| Antigen | TYK2 |
| Synonyms | Non-receptor tyrosine-protein kinase TYK2 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Cytoskeleton, Nucleus |
| Accession | P29597 |
| Clone Number | S-2740-165 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | MCF7, Jurkat, HeLa, U-87 MG, SH-SY5Y, Neuro-2a, mouse lung, C6, rat lung |
| Predicted Reactivity | Cz |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:2000-4000 | Hu, Ms, Rt |
| IHC-P | 1:100 | Hu, Ms, Rt |
Background
Tyrosine kinase 2 (TYK2) is a 1,187-residue Janus kinase that, by partnering with JAK1 to phosphorylate STAT1/2/3/4/5, transduces cytokine signals from IL-12, IL-23, type I IFNs and related receptors, thereby steering Th1/Th17 differentiation, antiviral and antitumor immunity; its unique pseudokinase–kinase domain architecture allows allosteric auto-inhibition, and human missense variants that weaken this brake—such as I684S, P1104A or the catalytic V362F—confer either protection against autoimmune diseases (by dampening IL-23-driven inflammation) or, conversely, risk of systemic lupus, psoriasis, multiple sclerosis and cancers, making selective TYK2 inhibitors like deucravacitinib promising therapies.
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